Published on September 22, 2025
4 min read
Hormone Replacement Therapy: Pros and Cons
Hormone Replacement Therapy (HRT) is often recommended to relieve symptoms of menopause in women and low testosterone in men.
It can improve quality of life by reducing hot flashes, improving mood, and supporting bone health.
However, like any treatment, HRT comes with both advantages and risks that must be carefully considered.
Whether you are considering estrogen, progesterone, testosterone, or a combination therapy, understanding the full picture of HRT is essential to making an informed health decision.
Below, we outline the key pros and cons of hormone replacement therapy.
Weighing the Benefits and Risks of HRT for Men and Women
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Pros of Hormone Replacement Therapy
- Relief from Menopausal Symptoms: HRT is highly effective in reducing hot flashes, night sweats, and vaginal dryness.
- Improved Bone Health: Estrogen-based HRT can reduce the risk of osteoporosis and fractures.
- Better Mood and Sleep: Many users report improved mental clarity, mood stability, and sleep quality.
- Supports Heart Health: In younger postmenopausal women, HRT may offer cardiovascular benefits when started early.
- Relief from Menopausal Symptoms: HRT is highly effective in reducing hot flashes, night sweats, and vaginal dryness.
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Cons of Hormone Replacement Therapy
- Increased Risk of Blood Clots: Especially with oral estrogen, there’s a higher chance of clot formation.
- Possible Risk of Breast Cancer: Long-term use of combination HRT (estrogen and progestin) may raise the risk.
- Not Suitable for Everyone: Women with a history of cancer, stroke, or liver disease may be advised to avoid HRT.
- Side Effects: These can include bloating, headaches, and mood swings, especially when adjusting doses.
- Increased Risk of Blood Clots: Especially with oral estrogen, there’s a higher chance of clot formation.